Intrapulmonary Pharmacokinetics and Pharmacodynamics of Posaconazole at 1 Steady State in Healthy Subjects
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Intrapulmonary pharmacokinetics and pharmacodynamics of posaconazole at steady state in healthy subjects.
We evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of posaconazole (POS) in a prospective, open-label study. Twenty-five healthy adults received 14 doses of POS oral suspension (400 mg twice daily) with a high-fat meal over 8 days. Pulmonary epithelial lining fluid (ELF) and alveolar cell (AC) samples were obtained via bronchoalveolar lavage, and blood samples were collected durin...
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تاریخ انتشار 2008